Liposome-plasmid complexes encoding angiostatin and endostatin inhibit breast cancer in nude mice
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منابع مشابه
Endostatin Inhibit Breast Cancer in Nude Mice Liposomes Complexed to Plasmids Encoding Angiostatin and Updated Version
Gene therapy transfer of angiostatin and endostatin represents an alternative method of delivering angiogenic polypeptide inhibitors. We examined whether liposomes complexed to plasmids encoding angiostatin or endostatin inhibited angiogenesis and the growth of MDA-MB-435 tumors implanted in the mammary fat pads of nude mice. We determined that plasmids expressing angiostatin (PCI-Angio) or end...
متن کاملLiposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice.
Gene therapy transfer of angiostatin and endostatin represents an alternative method of delivering angiogenic polypeptide inhibitors. We examined whether liposomes complexed to plasmids encoding angiostatin or endostatin inhibited angiogenesis and the growth of MDA-MB-435 tumors implanted in the mammary fat pads of nude mice. We determined that plasmids expressing angiostatin (PCI-Angio) or end...
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The c-los proto-oncogene has been implicated as a regulator of estro. gen.medlated cell proliferation. We have tested the tissue specificity and antitumor efficacy of a mouse mammary tumor virus-regulated antisense c-fos retroviral vector. Systemically administered vector could be detected in several tissues but was only expressed In breast epithelium, thus sup porting targeting to mouse mammar...
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Ovarian cancer is the leading cause of fatality among gynecological malignancies. Ovarian cancer growth is angiogenesis-dependent, and an increased production of angiogenic growth factors such as vascular endothelial growth factor is prognostically significant even during early stages of the disease. Therefore, we investigated whether antiangiogenic treatment can be used to inhibit the growth o...
متن کاملRecombinant adeno-associated virus 2-mediated antiangiogenic prevention in a mouse model of intraperitoneal ovarian cancer.
PURPOSE In the present study, we sought to determine the potential of sustained transgene expression by a single i.m. administration of recombinant adeno-associated virus 2 (rAAV) encoding angiostatin and endostatin in inhibiting i.p. ovarian cancer growth and dissemination in a preclinical mouse model. EXPERIMENTAL DESIGN Cohorts of female athymic nude mice received either no virus or 1.2 x ...
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ژورنال
عنوان ژورنال: Breast Cancer Research
سال: 1999
ISSN: 1465-542X
DOI: 10.1186/bcr-1999-66602